She co-wrote and starred in Showtime’s critically acclaimed comedy Fat Actress, and played the title character, as well as serving as executive producer, on the NBC sitcom Veronica’s Closet.

In 1994, Kirstie showcased her dramatic range starring in the CBS TV movie David’s Mother, for which she won her second Emmy. In 1987, she joined the cast of the long-running hit NBC sitcom, Cheers, as the neurotic Rebecca Howe. Kirstie received critical accolades and won both an Emmy for Lead Actress in a Comedy Series and Golden Globe for Best Performance by an Actress in a Comedy Series in 1991.

She made her movie debut in 1982 in Star Trek: The Wrath of Khan, in which she played beautiful Vulcan officer Lieutenant Saavik. In 1999, Kirstie starred in the dark comedy film Drop Dead Gorgeous, a cult-classic mockumentary that follows the contestants in a beauty pageant in Minnesota. She starred in Woody Allen’s Deconstructing Harry, and alongside John Travolta in the hit films Look Who’s Talking, Look Who’s Talking Too and Look Who’s Talking Now. Some of her other film credits include Shoot to Kill, Summer School, For Richer or Poorer and Champions.

In 1995, Kirstie was honored with a star on the Hollywood Walk of Fame. She served as the spokesperson for Pier One from 2000 to 2004, Jenny Craig from 2005 to 2008 and is currently the Poise Fairy. In 2010, Kirstie worked with experts in science, nutrition, and medicine to launch Organic Liaison, which includes Rescue Me, the first ever USDA certified organic weight-loss product. Kirstie has successfully lost 100 lbs using the program.